Captain Jack Sparrow finds the winds of ill-fortune blowing even more strongly when deadly ghost pirates led by his old nemesis, the terrifying Captain Salazar, escape from the Devil's Triangle, determined to kill every pirate at sea...including him. Captain Jack's only hope of survival lies in seeking out the legendary Trident of Poseidon, a powerful artifact that bestows upon its possessor total control over the seas.
The checkered past of Capt. Jack Sparrow (Johnny Depp) catches up to him when he encounters Angelica (Penélope Cruz), a beautiful pirate that Jack once loved then left. Angelica forces him to accompany her to the Queen Anne's Revenge, the ship of the notorious Blackbeard (Ian McShane). Accompanied by a zombie crew, the trio sets sail to find the legendary Fountain of Youth. However, Jack's rival, Barbossa (Geoffrey Rush), also seeks the fountain, as does a ship from Spain.
When ghostly pirate Davy Jones (Bill Nighy) comes to collect a blood debt, Capt. Jack Sparrow (Johnny Depp) must find a way to avoid his fate lest his soul be damned for all time. Nevertheless, the wily ghost manages to interrupt the wedding plans of Jack's friends Will Turner (Orlando Bloom) and Elizabeth Swann (Keira Knightley).
In 1805, aboard the H.M.S. Surprise, the brash Captain Jack Aubrey (Russell Crowe) and his trusted friend, the ship's scholarly surgeon, Stephen Maturin (Paul Bettany), are ordered to hunt down and capture a powerful French vessel off the South American coast. Though Napoleon is winning the war and the men and their crew face an onslaught of obstacles, including their own internal battles, "Lucky Jack" is determined that nothing will stop the Surprise from completing its mission.
In the South Pacific island of Makatea, career-driven magazine editor Robin Monroe (Anne Heche) is on a week-long vacation getaway with her boyfriend, Frank Martin (David Schwimmer). A work assignment in neighboring Tahiti requires Robin to hire a cargo plane piloted by the cantankerous Quinn Harris (Harrison Ford). But when a powerful storm forces Quinn to make an emergency landing on a nearby deserted island, the dissimilar pair learn to set aside their differences in order to find rescue.