Thanks to the success of officers Jenko (Channing Tatum) and Schmidt (Jonah Hill), who went undercover as high school kids to take down a drug ring, the police department invests a lot of money in keeping the Jump Street program going. There's just one snag — the Koreans bought their church at 21 Jump Street back, so the police move the program's headquarters across the road to the Catholic church at 22 Jump Street. Once again reporting to Captain Dickson (Ice Cube), the boys are assigned to go undercover at a local college. Their friendship takes a toll when Jenko shows interest in the football team while Schmidt breaks into the art major scene. In addition to cracking the case, they have to learn to have a mature relationship, if that's possible for these two overgrown adolescents.
When Shelly, a Playboy bunny, is tossed out of the mansion, she has nowhere to go until she falls in with the sorority girls from Zeta Alpha Zeta. The members of the sorority - who also have got to be the seven most socially clueless women on the planet - are about to lose their house. They need a dose of what only the eternally bubbly Shelley can provide... but they will each learn on their own to stop pretending to be what others want them to be and start being themselves.